Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 51 0.0 0.465 0.03 0.084
biological_process el 51 0.011 0.966 0.619 0.244
biological_process ka 51 0.0 0.443 0.028 0.078
biological_process rf 51 0.0 0.465 0.03 0.084
cellular_component ct 51 0.0 0.583 0.054 0.107
cellular_component el 51 0.005 0.973 0.515 0.278
cellular_component ka 51 0.0 0.579 0.057 0.11
cellular_component rf 51 0.0 0.583 0.054 0.107
disease ct 13 0.001 0.839 0.174 0.25
disease el 13 0.005 0.791 0.322 0.259
disease ka 13 0.0 0.943 0.189 0.282
disease rf 13 0.001 0.839 0.174 0.25
genetic_interaction ct 47 0.0 1.0 0.389 0.332
genetic_interaction el 47 0.0 1.0 0.418 0.347
genetic_interaction ka 47 0.0 1.0 0.915 0.279
genetic_interaction rf 47 0.0 1.0 0.407 0.342
molecular_function ct 51 0.0 0.797 0.025 0.113
molecular_function el 51 0.029 0.958 0.51 0.292
molecular_function ka 51 0.0 0.774 0.029 0.114
molecular_function rf 51 0.0 0.797 0.025 0.113
pathway ct 26 0.001 0.996 0.059 0.19
pathway el 26 0.001 0.185 0.017 0.037
pathway ka 26 0.001 1.0 0.273 0.442
pathway rf 26 0.001 0.15 0.02 0.034
phenotype ct 14 0.0 0.881 0.296 0.318
phenotype el 14 0.03 0.837 0.456 0.217
phenotype ka 14 0.0 0.968 0.333 0.35
phenotype rf 14 0.0 0.882 0.296 0.318
protein_interaction ct 53 0.0 0.741 0.024 0.105
protein_interaction el 53 0.0 0.779 0.027 0.111
protein_interaction ka 53 0.001 1.0 0.214 0.402
protein_interaction rf 53 0.0 0.74 0.023 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 53 0.0 0.711 0.028 0.103
integration_mean_by_presence el 53 0.0 0.703 0.121 0.159
integration_mean_by_presence ka 53 0.0 0.794 0.022 0.109
integration_mean_by_presence rf 53 0.0 0.295 0.021 0.055
mean ct 53 0.0 0.66 0.019 0.094
mean el 53 0.0 0.53 0.047 0.098
mean ka 53 0.0 0.565 0.017 0.079
mean rf 53 0.0 0.29 0.028 0.07

CDF plots of non integrated kernels

CDF plots of integrated kernels